THIS IS THE YEAR THAT WAS: THE BEST OF THE JOURNAL OF GERONTOLOGY BIOLOGICAL SCIENCES

Abstract The Journal of Gerontology Biological Sciences (JGBS) is one of the Gerontological Society of America publications. It publishes articles on the biological aspects of aging in areas such as translational gerontology, biomarkers of aging, biochemistry, biodemography, cellular and molecular biology, and geroscience. Biological insights are also published in studies from invertebrates, vertebrates, and mammalian species, including humans. With an impact factor of 6.59, this journal is one of the leading journals in the field. Overall, and although the journal is highly valued by biomedical researchers worldwide, the authors of our top and most impactful papers do not usually have the opportunity to answer the questions from their peers constructively and interactively. In addition, there is a significant number of biomedical researchers that, although members of the Society, do not submit their best results to the journal. This symposium, chaired by the Editor-in-Chief of the JGBS, will comprise six presentations by the authors of the most influential papers of the year (June 2022 to June 2023). The papers will be selected based on their impact via citations and/or social media. Presenters will be chosen following diversity, equity, and inclusion principles. Various topics going from cells to animal models will be covered while highlighting the translational potential of those discoveries. Ten minutes presentation will be followed by 5 minutes of Q&A with ample opportunity to interact.

Ting Yong, Abhijit Visaria, and Rahul Malhotra, Duke-NUS Graduate Medical School, Singapore, Singapore In ageing societies, more older adults are taking up informal caregiving roles.Caregivers, compared to noncaregivers, are found to have poorer psychosocial outcomes such as loneliness and social isolation in various studies.However, most of this research is not specific to older adult caregivers and does not account for selection bias into caregiving.We compare loneliness and social network between older adult caregivers and older adult non-caregivers in Singapore, applying inverse probability weighted regression adjustment (IPWRA), to address selection bias into caregiving, on data from a nationally representative longitudinal study of older adults.Those providing unpaid assistance to any person because of their health condition were considered as caregivers.Loneliness (score: 0-12; higher score=lonelier) and social network (0-60; higher score=greater network) were measured using validated scales.The relationship of caregiving status with loneliness and social network was estimated using IPWRA, controlling for multiple demographic and health characteristics.Of the 2639 respondents, 7.2% were caregivers.Older adult caregivers, versus non-caregivers, were more likely to experience loneliness (average treatment effect [ATE] β-coefficient for loneliness score: 0.328 (95% confidence interval: 0.011-0.645;p-value: 0.042); and odds ratio for being lonely: 1.080 (1.001-1.165);p-value: 0.047).However, they did not differ in terms of their social network (ATE β-coefficient for social network score: 1.456 (-0.405-3.316);p-value: 0.125).Our findings suggest that even with a similar extent of social network, older adult caregivers are at a higher risk of loneliness, i.e., perceived social isolation or relational deficits, compared to non-caregivers.
Abstract citation ID: igad104.0060William McConnell, Katherine Haggar, and María Ortega Hernández, Florida Atlantic University, Boca Raton, Florida, United States Over half of the older adults with Alzheimer's disease and related dementias (ADRD) live in the community with informal caregivers whose unpaid assistance constitutes the majority of their care.Research and interventions targeting caregivers typically limit their focus to one primary caregiver, but many older adults with ADRD rely on a variety of interconnected kin, non-kin, and professional supporters.Little is known about the structure, composition, or consequences of these caregiver networks.To address this gap, we conducted a social network analysis (SNA) of the caregiver networks of 23 older adults with ADRD receiving outpatient services at a Memory Disorder Clinic.SNA data was obtained through detailed social network interviews conducted one-on-one with self-identified primary caregivers.We find that adults with ADRD have an average of 7.7 caregivers in their networks.Quantitative analyses demonstrate that caregiver network properties (including size, density, composition, and care coordination) vary with the context of caregiving (including living situation, level of functional impairment, and use of formal services).An average network includes a roughly even mix of informal caregivers (3.2 members) and professional caregivers (3.5), but they occupy different network positions and fill distinct supportive roles.For example, informal caregivers engage in frequent care coordination, but coordination is comparatively uncommon between formal caregivers.This interdisciplinary research advances beyond the dyadic level of analysis typical of most caregiving research to comprehensively measure caregiver networks.Further, we identify variations in caregiver networks and quantify network-based task-sharing and care coordination among informal and professional caregivers.Care networks are defined as the collection of individuals who provide support for older adults with health challenges.Although many older adults receive care from multiple caregivers, with varying intensities of caregiving, little is known about the structure of their care networks and whether or to what extent it changes over time.This study aims to examine the stability of care networks and the predictive effects of static and dynamic factors on patterns of caregiving networks.Using data from the National Health Aging Trends (NHAT) and National Study of Caregiving (NSOC), we examine the static and dynamic intrapersonal structures of care arrangements with regard to systematic continuity across 7 years.We utilize both Latent Profile Analysis and Latent Transition Analysis to identify different types of caregiving arrangements and patterns of transitions over time.Moreover, we use logistic regressions to examine how individual and time-varying factors affect those arrangements and transitions.The results show three groups of caregiving arrangements: 1) intense care with one caregiver, 2) moderate-level care with multiple caregivers, and 3) low-level care with multiple caregivers.Among the groups, moderate-level care with multiple caregivers is the most stable group.Moreover, static factors, such as gender and race, and dynamic factors, such as psychological resilience of care recipients, significantly impacts the probability of transitioning from low-level care to intense care over time.The findings highlight the utility of Latent Transition Analysis in caregiving networks, suggesting that patterns of caregiving outcomes should be understood as process as well as a condition.

THIS IS THE YEAR THAT WAS: THE BEST OF THE JOURNAL OF GERONTOLOGY BIOLOGICAL SCIENCES Chair: Gustavo Duque
The Journal of Gerontology Biological Sciences (JGBS) is one of the Gerontological Society of America publications.It publishes articles on the biological aspects of aging in areas such as translational gerontology, biomarkers of aging, biochemistry, biodemography, cellular and molecular biology, and geroscience.Biological insights are also published in studies from invertebrates, vertebrates, and mammalian species, including humans.With an impact factor of 6.59, this journal is one of the leading journals in the field.Overall, and although the journal is highly valued by biomedical researchers worldwide, the authors of our top and most impactful papers do not usually have the opportunity to answer the questions from their peers constructively and interactively.In addition, there is a significant number of biomedical researchers that, although members of the Society, do not submit their best results to the journal.This symposium, chaired by the Editor-in-Chief of the JGBS, will comprise six presentations by the authors of the most influential papers of the year (June 2022 to June 2023).The papers will be selected based on their impact via citations and/or social media.Presenters will be chosen following diversity, equity, and inclusion principles.Various topics going from cells to animal models will be covered while highlighting the translational potential of those discoveries.Ten minutes presentation will be followed by 5 minutes of Q&A with ample opportunity to interact.

GENTRIFICATION, AGING, AND HEALTH: A NARRATIVE REVIEW Dionne Bailey, University of Minnesota, Minneapolis, Minnesota, United States
Multiple definitions of gentrification exist, and the lack of consensus about what constitutes gentrification has limited the efforts of this concept's measurement/operationalization as well as an understanding of how gentrification influences outcomes, particularly for older adults.The objective of this literature review is to synthesize existing definitions and measurement approaches to gentrification in studies of older adults and their communities.Another objective is to summarize the health implications of gentrification for older adults.OVID Medline, CINAHL, Academic Search Premier, PsycINFO, and Scopus were searched in order to identify peer-reviewed articles that were published up to August 2022.'Gentrification' and 'Aging' were the keywords utilized to search for peer-reviewed articles.Post abstract screening, each article was annotated to identify key study characteristics and tabulated to identify patterns and themes.Fortynine articles were identified and extrapolated.The analysis revealed inconsistencies in the definition of gentrification, which lead to mixed findings related to the health effects of gentrification for older people.Specifically, it was found that there are both positive and negative effects of gentrification.The most consistent findings evident were that minorities were most at-risk during periods of gentrification, particularly Black older adults.It is imperative that a scientific consensus is reached when defining and subsequently operationalizing gentrification.Such refinements will result in more robust and rigorous quantitative and qualitative research that describes the health implications and/or lived experiences of gentrification for older adults.Older adults benefit from community programs that promote physical and mental health, reduce social isolation, and offer connections to community resources.However, older adults living in rural communities have access to fewer health and social services and experience barriers to participation such as access to transportation.Recognizing

LIVING FOREVERWELL IN RURAL AMERICA: RESULTS FROM A QUALITATIVE EVALUATION OF A YMCA HEALTHY AGING PROGRAM
Rachel Kappel 1 , Alycia Bayne 1 , Shena Popat 1 , Mabel Frank 1 , Seana Hasson 2 , and Lindsay Mondick 3 , 1. NORC at the University of Chicago, Chicago, Illinois, United States, 2. YMCA of the USA, Chicago, Illinois, United States, 3. YMCA of the USA, Eagan, Minnesota, United States